Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. Compared with opioids, which bind to µ-opioid receptors while in the central anxious technique, conolidine modulates alternate molecular targets. A Science Advances review found that conolidine interacts Using the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://gunnerbbync.suomiblog.com/alternative-natural-pain-relief-to-replace-traditional-painkillers-options-54832581