There exists a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors inside the dorsal horn to reduce afferent soreness transmission and deliver analgesia. Thus, medicine like clonidine that target alpha-2 receptors can impact the transmission of soreness. Among the theories concerning the mechanism of https://www.proleviate.com/post/the-new-pain-killer-conolidine