Epidural clonidine employed as an adjunct to regional anesthetics has a few various mechanisms of action. 1st, the stimulation of alpha-2-receptors while in the dorsal horn reduces pain transmission. Secondly, clonidine may cause regional vasoconstriction that restrictions vascular elimination of local epidural anesthetics. Could possibly be provided as monotherapy https://www.proleviate.com/post/the-new-pain-killer-conolidine