There's a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to lessen afferent pain transmission and produce analgesia. Hence, medication like clonidine that target alpha-2 receptors can affect the transmission of discomfort. Might be offered as monotherapy or as adjunctive https://ricardorpnmk.sasugawiki.com/7155486/new_step_by_step_map_for_onolidine