Topical Treatment options About-The-Counter Medicine Around-the-counter creams and ointments, Primarily people who have capsaicin, an extract derived from chili peppers, might be used topically on the knee that can help reduce pain by decreasing the depth of pain alerts sent along nerve pathways. Those who just take NSAIDs or coxibs https://www.theorthopaedicandpainpractice.com/understanding-and-treating-elderly-knee-pain/