Does Creatine Lead to Constipation? Creatine is a popular nutritional supplement used by athletes and bodybuilders to extend muscle mass mass. Though it's been demonstrated to be successful in aiding persons Construct strength, there are some possible Negative effects which have been linked with creatine use, including constipation. https://wellnessprosper.com/does-creatine-cause-constipation-exploring-the-potential-link/